[antihemophilic Globulin Consumption during Blood Coagulation].
نویسنده
چکیده
منابع مشابه
Comparison of effects of protamine and polybrene, with special emphasis on the factor VIII (antihemophilic globulin) deficiency induced.
Successful achievement of extracorporeal circulation requires that blood coagulability be temporarily interrupted during perfusion and afterward restored to normal. Heparin is accepted as the drug of choice in rendering the blood incoagulable, but there are two drugs, protamine and Polybrene (hexadimethrine bromide), available for effective in vivo neutralization of heparin, and controversy exi...
متن کاملThe coagulation defect in hemophilia with particular reference to the conversion of prothrombin to thrombin and the evolution of the prothrombin conversion accelerator.
taneously increase prothrombin consumption. The latter author used this effect as a basis for assay of the antihemophilic activity of normal plasma. Recently, substances have been described which, arising in blood during its coagulation, accelerate the conversion of prothrombin to thrombin in the presence of thromboplastin plus calcium.3’ Their evolution and physiologic properties help cxplain ...
متن کاملThe importance of activation of antihemophilic globulin and proaccelerin by traces of thrombin in the generation of intrinsic prothrombinase activity.
seconds.2 Therefore, although the PTT measures the over-all time of the intrinsic clotting reactions, in most circumstances it essentially measures the rate of generation of intrinsic prothrombinase. It is now generally accepted that contact with a negatively charged surface such as glass initiates clotting in vitro by activating Hageman factor ( HF, factor XII ) . Activated HF then reacts with...
متن کاملCross-Linking of Cold-insoluble Globulin by Fibrin-stabilizing
Cold-insoluble globulin (CI globulin) was purified from human plasma and identified on the basis of its sedimentation coefficient, electrophoretic mobility, and concentration in normal plasma. CI globulin was distinguished from antihemophilic factor (AHF) by amino acid analysis, position of elution from 4% agarose, and electrophoretic migration in polyacrylamide gels in the presence of sodium d...
متن کاملCross-linking of cold-insoluble globulin by fibrin-stabilizing factor.
Cold-insoluble globulin (CI globulin) was purified from human plasma and identified on the basis of its sedimentation coefficient, electrophoretic mobility, and concentration in normal plasma. CI globulin was distinguished from antihemophilic factor (AHF) by amino acid analysis, position of elution from 4% agarose, and electrophoretic migration in polyacrylamide gels in the presence of sodium d...
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ورودعنوان ژورنال:
- Blood
دوره 11 5 شماره
صفحات -
تاریخ انتشار 1956